| ncRNA name | mmu-miR-195a-3p |
| ncRNA Category | miRNA |
| Disease name | choroidal neovascularization (CNV) |
| Species | Mus musculus |
| Tissues/Cell_line | mesenchymal stem cells (MSCs) |
| Methods | Transient transfection, qRT-PCR, Western blot, luciferase reporter assay |
| Expression pattern | down-regulated |
| Functional description | Matrix metalloproteinase 2 (Mmp2) transcript is a target of miR-195a-3p, and that silencing Mmp2 phenocopied the reduced proliferation and migration of MSCs. The therapeutic potential of miR-195a-3p as an angiogenesis inhibitor was also demonstrated in a laser-induced choroidal neovascularization mouse model. |
| PubMed ID | 26989874 |
| Year | 2016 |
| Title | MicroRNA-195a-3p inhibits angiogenesis by targeting Mmp2 in murine mesenchymal stem cells. |
| Drug-related ncRNA | NO |
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